YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
家兎におけるスルフイソキサゾールの体内動態に及ぼすサリチル酸とサリチルアミドの影響
今村 順茂宮下 英一小田切 優樹
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ジャーナル フリー

1986 年 106 巻 12 号 p. 1146-1150

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Salicylic acid markedly reduced the blood concentration of sulfisoxazole after oral administration. On the other hand, salicylamide markedly enhanced the blood concentration of sulfisoxazole after oral administration. In addition, the effects of salicylic acid and salicylamide on sulfisoxazole disposition were examined. The results indicated that salicylic acid affects the processes involved in the absorption and distribution of sulfisoxazole, while salicylamide affects the process involved in the elimination of sulfisoxazole.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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