1986 年 106 巻 12 号 p. 1146-1150
Salicylic acid markedly reduced the blood concentration of sulfisoxazole after oral administration. On the other hand, salicylamide markedly enhanced the blood concentration of sulfisoxazole after oral administration. In addition, the effects of salicylic acid and salicylamide on sulfisoxazole disposition were examined. The results indicated that salicylic acid affects the processes involved in the absorption and distribution of sulfisoxazole, while salicylamide affects the process involved in the elimination of sulfisoxazole.