ヒトにおけるフロセミドの消失と利尿効果
1986 年 106 巻 3 号 p. 221-227
詳細
1986 年 106 巻 3 号 p. 221-227
Four doses (5, 10, 20, 40mg) of furosemide were orally administered to 3 healthy male subjects. Urine samples were collected after predetermined time intervals and urinary excretions of the drug, Na+ and K+ were determined as well as urine volumes. Linear relationship was observed between increments ofcumulative Na++K+ excretion and urine volumes. Durations of diuretic response were about 3 h regardless of the dose administered, thereafter, Na++K+ excretions and urine volumes were below control levels. Three-hour cumulations of urinary Na++K+ excretion increments were linearly related to logarithm of the amount of furosemide administered.
