1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第9報)Flutazolamの加水分解生成物の中枢作用

抄録

Effects of hydrolizate (III·HCl) of Flutazolam (I) on the antianxiety, the anticonvulsion, the prolongation of the sleep, the muscle relaxation and the antihypoxia were compared with I in mice by the established methods. It was demonstrated that III·HCl inhibited the anxiety and pentetrazol-induced convulsion, prolonged the thiopental-induced sleep, and produced the skeletal muscle relaxation and the protection against hypobaric-hypoxia. These potencies of III·HCl were equipotent to I. These results suggested that III·HCl might be able to be delivered in an injection form.