非ステロイド性抗炎症剤EB-382の抗アレルギー作用
1987 年 107 巻 2 号 p. 170-174
詳細
1987 年 107 巻 2 号 p. 170-174
The anti-allergic effects of EB-382, a non-steroidal antiinflammatory agent, were examined on the experimental animal models of allergic reactions. EB-382 showed no inhibition against the heterologous passive cutaneous anaphylaxis reaction in guinea-pigs (type I). EB-382 suppressed significantly the active Arthus reaction in rabbits at doses of 3 and 10 mg/kg, p.o. and the reversed passive Arthus reaction in guinea-pigs at a dose of 3 mg/kg, p.o. (type III), respectively. EB-382 showed no inhibition on the complement fixation reaction of sheep erythrocytes in vitro (type II) and the tuberculin-induced delayed type allergic reaction in guinea-pigs (type IV). It is suggested that EB-382 is a new type of non-steroidal antiinflammatory agent with a precedent pharmacological action, since it shows an inhibitory effect on the experimental model of type III of allergic reaction.
