1987 年 107 巻 3 号 p. 199-208
It was found that the subcutaneous treatment with 0.6 mg/kg of methotrexate (MTX) twice a week for 7 weeks in rat led to the increases in blood viscosity-adjusted hematocrit and serum lipidperoxide level and a decrease in the expansibility of erythrocyte during the course of hypotonic hemolysis. The effect of sho-saiko-to, one of the useful kampo prescriptions used in traditional Chinese system of medicine, on biological responses in MTX-treated rats was examined mainly from the biorheological view points. The combined use of sho-saiko-to and MTX inhibited the blood flow properties affected by MTX treatment. It was also found that the administration of sho-saiko-to inhibited the decrease of body weight and the increase of liver lipidperoxide induced by MTX treatment. The MTX-induced increase of liver lipidperoxide level was also restored by the administration of mecobalamin which showed no effect on the blood viscosity and body weight affected by MTX treatment.