YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ウイルスと死に至る病
日沼 頼夫
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ジャーナル フリー

1988 年 108 巻 10 号 p. 938-941

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Retroviridae is a large family of medium-sized enveloped viruses with a complex structure and remarkable enzyme, reverse transcriptase. Uniquely among viruses, the genome is diploid and consists of an inverted dimer of single strand positive-sense ribonucleic acid (RNA).The deoxyribonucleic acid (DNA) copy of the viral genome transcriptase is integrated into the cellular DNA before multiplication occurs. The retroviridae is subdivided into three subfamilies, only two of which are important in human medicine.The subfamily oncoviridae includes the adult T-cell leukemia virus (HTLV-I) while the virus associated with acquired immune deficiency syndrome (AIDS) is a member of the lentiviridae subfamily. Although AIDS virus (HIV) shares its targets cell tropism and ability to form syncytia in the cells with ATLV/HTLV-I. ATLV is endemic in Japan, Africa and Papua New Guinea.ATLV is a very old virus since its origin is probably the same as that of human population.In contract, HIV is a quite new virus which occurred only recent some ten years but the virus has been spread among people in many areas including north and south America, Australia, Europe and Africa.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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