有害性金属に関する研究 (第20報) 無機水銀の分布と排泄に及ぼすキレート剤の影響

抄録

The effects of three chelating agents, sodium N-benzyl-o-glucamine dithiocarbamate (NBG-DTC), 2, 3-dimercaptopropanol (BAL), and D-penicillamine (D-PEN), on the distribution and excretion of inorganic mercury were compared in rats exposed to HgCl₂. Rats were injected i. p. with ²⁰³HgCl₂ (300μg and 2μCi of ²⁰³Hg/kg) and after 24h they were treated with the chelating agents (a quarter of an LD₅₀) every day for 7d. NBG-DTC and BAL promoted fecal and urinary excretions of mercury, while o-PEN promoted urinary excretion of mercury. NBG-DTC and BAL reduced the contents of mercury in the liver and kidney. BAL reduced the contents of mercury in the spleen, testes, heart, pancreas, and lung. D-PEN reduced only the content of mercury in the kidney. These chelating agents did not result in a redistribution of mercury to the brain, heart, and lung. The treatment with these chelating agents decreased the amounts of Zn, Fe, Cu, and Mn in the tissue as compared with control. The growth of rats was little retarded by treatment with these chelating agents. There was no damage to the liver and kidney by treatment with NBG-DTC. The results of this study reveal that the injection of NBG-DTC to rats pretreated with mercury can effectively remove mercury from the body as well as the injection of BAL.