エイズとHuman Immunodeficiency Virus(HIV), そしてその薬物療法
1988 年 108 巻 2 号 p. 83-90
詳細
1988 年 108 巻 2 号 p. 83-90
Acquired immunodeficiency syndrome(AIDS) is a pandemic immunosuppressive disease which results in life-threatening opportunistic infections and malignancies. A retrovirus, designated human immunodeficiency virus (HIV), has been isolated and identified as the etiologic agent of this disease. Recently, some compounds have been evaluated for their inhibitory effects on HIV replication in vitro, e.g. ribavirin, phosphonoformic acid, recombinant interferon-α, 2, 3'-azido-2', 3'-dideoxythymidine, 2', 3'-dideoxynucleosides and glycyrrhizin. Clinical trials have been also initiated with most of these compounds, although results of these trials cannot be fully interpreted. In view of the uniqueness of HIV infection it is essential to understand the mode of infection and replication of HIV for the chemotherapeutic approaches to the treatment of AIDS.
