YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
2-Aminoalkylpyridine をキャリヤーリガンドとする白金錯体の合成とその制癌活性について
森川 一実本多 成光遠藤 弘一松本 智子赤松 健一光井 碩樹小泉 益男
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1988 年 108 巻 4 号 p. 317-324

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Platinum complexes of 2-aminoalkylpyridine as a carrier ligand were synthesized and evaluated for antitumor activities against P388 leukemia in mice. Among the analogues, (2-aminomethylpyridine)oxalatoplatinum (II) (X1), (2-aminomethylpyridine)malonatoplatinum (II) (X2), (2-aminomethylpyridine)(1, 1-cyclobutanedicarboxylato)platinum (II) (X3), (2-(1-aminoethyl)pyridine)oxalatoplatinum (II) (X12) and (2-(1-aminopropyl)pyridine)oxalatoplatinum (II) (X17) exhibited excellent activity and were comparable to cis-diamminedichloroplatinum (II) and superior to (1, 1-cyclobutanedicarboxylato)diammineplatinum (II). Structure-activity relationships are discussed.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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