YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
(Na++K+)-Adenosinetriphosphatase(ATPase)アイソザイムの生理的意義
松田 敏夫
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ジャーナル フリー

1990 年 110 巻 4 号 p. 235-245

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Since Sweadner demonstrated that there are two isozymes (α and α (+) isoforms) of (Na++K+)-adenosine triphosphatase (ATPase) in the brain about 10 years ago, the isozymes have been extensively studied at biochemical and molecular levels. We started the studies on the isozymes of (Na++K+)-ATPase soon after finding that pyrithiamin, an antimetabolite of thiamin is a selective inhibitor of the α (+) isoform. This review summarizes the previous studies on the isozymes of (Na++K+)-ATPase, which are now classified into α1, α2, and α3.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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