発癌性N-ニトロソジアルキルアミンの代謝活性化
1990 年 110 巻 6 号 p. 359-373
詳細
1990 年 110 巻 6 号 p. 359-373
Chemical and biological properties of metabolically activated species of carcinogenic N-nitrosodialkylamines are reviewed. α-Hydroxy nitrosamines and their derivatives ; α-acetoxy nitrosamines, α-hydroperoxy nitrosamines, α-phosphonooxy nitrosamines and alkanediazotates are included. Metabolic deactivation through denitrosation and metabolic activation through β-oxidation are also mentioned.
