YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
アスボキシシリン分解物の研究(第2報)アスボキシシリンの重合物系分解物
柳田 正小島 幸雄山崎 一矢大良 勇石川 勉絹巻 明生我妻 光吉
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1990 年 110 巻 6 号 p. 400-406

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Intermolecular condensation of a novel semisynthetic penicillin, aspoxicillin (ASPC) was studied. Several products with small amounts on standing in an aqueous solution at room temperature were detected by the amide-bond formation between a primary amine at the side chain and a lactam carbonyl of another molecule. Their structures were estimated to be a dimer, epi-isomer of dimer, a trimer, and their analogues of the β-lactam ring opening. This polymerization reaction is known to occur in penicillins such as ampicillin and amoxicillin with the primary amine group at the benzylic position.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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