YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
画像処理による白朮の抗潰瘍作用とその作用成分
松田 久司李 育浩谷口 久美子山原 條二玉井 洋進
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1991 年 111 巻 1 号 p. 36-39

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Examination of the sizes of gastric mucosal injury has been conducted by visual means. However, the human visual-eye examination may sometimes involve personal biases and errors. In order to reduce these errors, automated analytical apparatuses have been developed. The equipment is generally expensive. In the present study, a low-cost imaging analytical method to examine the antiulcer action of drugs is reported. By using our imaging analytical method, an antiulcer effect of herbal medicine was examined on hydrochrolic acid-ethanol induced gastric mucosal injury. Acetone extract of Atractylodis Rhizoma was found to have antiulcer action. In addition, the examination of fractions of the acetone extract, obtained through column chromatography, indicated that atractylon, at 17.5mg/kg, p.o. significantly inhibits gastric mucosal injury.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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