YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
常山の抗補体活性物質の研究。ステロイド誘導体の抗補体作用
海老原 毅川合 智子黒柳 正典福島 清吾上野 明
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1991 年 111 巻 6 号 p. 299-305

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Methanol extracts of 53 crude drugs were tested on the anticomplementary activity. Of these, 12 samples showed the potent activity. Of these 12 samples, the extract of Jozann (Dichrome Radix) was studied on the isolation and structural elucidation of the anticomplementary constituents. As active constituents, 3β-hydroxystigmast-5-en-7-one was isolated and its structure was confirmed by deriving this compound from β-sitosterol. The activity of such steroid derivatives as stigmastane, cholestane, androstane and pregnane type steroids were further studied. Of these, several kinds of steroids showed the potent activity. From these experiments, the structure and activity relationship was discussed.

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