YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
放射線障害防護薬剤に関する研究(第34報)放射線障害に対する各種漢方方剤水エキスの延命効果
王 誠明太田 節子篠田 雅人
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ジャーナル フリー

1991 年 111 巻 6 号 p. 322-328

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In order to develop a nontoxic radioprotector, 60 kinds of Chinese traditional medicines were chosen, and their aqueous extracts tested for their survival effects against the lethal effect of X-irradiation in mice. Radiation factors used were as follows : soft X-rays, 2100R (5.418×10-1Ckg-1), 70 kVp, 10 mA, 10 mm acrylic filter, 70R (1.806×10-2Ckg-1)/min. Among 60 medicines tested by intraperitoneal injection immediately before the irradiation, 15 are shown to have the significant survival effect. These 15 effective medicines were also tested by intraperitoneal injection after the irradiation, and the survival effect was recognized in Keisi-syakuyaku-chimo-to, Keigai-rengyo-to, Simotu-to, Syakuyaku-kanzo-to and Hange-syasin-to. On the other hand, the survival effects of 25 medicines including the above-mentioned 15 medicines were investigated by the oral administration at various times before or after the irradiation. As the result of these studies, only Keigai-rengyo-to and Bukuryo-in are shown to have the significant survival effect when administered 2 h before the irradiation.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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