1994 年 114 巻 5 号 p. 277-303
In this review, I wish to summarize studies on sialic acid-N-acetylneuraminic acid (Neu 5Ac), N-glycoloylneuraminic acid (Neu 5Gc), 3-deoxy-D-glycero-D-galacto-nonulopyranosonic acid (KDN), and their alkyl, acyl, dehydro and deoxy derivatives. Our working strategy is"cell component derivatives of sialic acid which have a good shape and good balance between hydrophilicity and hydrophobicity, would elicit various kinds of physiological activities."Preparation and physiological activities of sialic acid derivatives, and a new method of stereochemistry determination are reported. Several derivatives show remarkable physiological activities for novel medicines in the XXI century. A generic name'GLYCOLIPOID'is proposed for such compounds.