YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
シアル酸をリード化合物とする生理活性物質の探索
小倉 治夫
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ジャーナル フリー

1994 年 114 巻 5 号 p. 277-303

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In this review, I wish to summarize studies on sialic acid-N-acetylneuraminic acid (Neu 5Ac), N-glycoloylneuraminic acid (Neu 5Gc), 3-deoxy-D-glycero-D-galacto-nonulopyranosonic acid (KDN), and their alkyl, acyl, dehydro and deoxy derivatives. Our working strategy is"cell component derivatives of sialic acid which have a good shape and good balance between hydrophilicity and hydrophobicity, would elicit various kinds of physiological activities."Preparation and physiological activities of sialic acid derivatives, and a new method of stereochemistry determination are reported. Several derivatives show remarkable physiological activities for novel medicines in the XXI century. A generic name'GLYCOLIPOID'is proposed for such compounds.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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