YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
新規アクリジン誘導体のトポイソメラーゼII依存性DNA鎖切断活性とマウス白血病P388抗がん活性
木邑 道夫
著者情報
ジャーナル フリー

1994 年 114 巻 5 号 p. 304-307

詳細
抄録

In order to clarify the mechanism of topoisomerase II mediated DNA cleavage activity caused by intercalators (9-anilinoacridines), antitumor activities against murine P388 and calf thymus DNA topoisomerase II mediated DNA cleavage activities of compounds m-AMSA, A4P73, A3P56, and A3P166 have been studied. A4P73 was found to have potent antitumor and DNA cleavage activities.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top