YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
高次有機銅試薬を用いるgem-ジブロモシクロプロパン体のアルキル化反応について
原山 尚小林 英夫西田 寛子石井 永
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ジャーナル フリー

1995 年 115 巻 10 号 p. 863-870

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The reaction of gem-dibromocyclopropanes (1) with a higher-order organocuprate prepared from CuCN and commercially available MeLi, followed by the addition of MeI in situ, afforded dimethylcyclopropanes (2) in good yields. The differential substitution reaction of dibromide (1a) in one pot with the higher-order organocuprate and allyl bromide gave a compound (8) in the moderate selectivity as shown in Table 3. Its stereochemistry was deduced by the reaction mechanism.

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