YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
新規な1,4-ジヒドロピリジン系Ca拮抗薬CS-905の研究(第1報)液体クロマトグラフ(HPLC)法による分配係数(logP)の測定
益本 和枝武安 明大泉 喜代志古林 隆司
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1995 年 115 巻 3 号 p. 213-220

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A new 1, 4-dihydropyridine derivative, CS-905, currently under development as a Ca antagonist, showed a gradual onset and long duration in its antihypertensive effect upon single oral administration. The partition coefficient for CS-905 was measured along with 11 known dihydropyridine Ca antagonists by the HPLC method to clarify its mode of action. The log PHPLC for CS-905 was, 5.18, almost the same as that of manidipine and this value is the highest among the measured drugs. Its pharmacokinetic profile in SHR was also discussed.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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