YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ハイブリッド型リポソームのin Vitroでの抗腫瘍効果
今村 主税金納 明宏光岡 ちほみ北島 俊一井上 秀顕岩原 正宜松本 陽子上岡 龍一
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1996 年 116 巻 12 号 p. 942-950

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Remarkably high inhibitory effects of the hybrid liposomes composed of L-α-dimyristoyl-phosphatidylcholine (DMPC) and polyoxyethylenealkyl ether (C14 (EO)n, n=6-8 and C12 (EO)n, n=8-12)) on the growth of human lymphoma-human B-lymphocyte hybridoma (HF) cells in vitro were obtained. The hybrid liposomes composed of 90 mol% DMPC/10mol% C14 (EO)n (n=6-8) or C12 (EO)n (n=8-12) were more fluid as compared with 90mol% DMPC/10 mol% C14 (EO)4 or C12 (EO)n (n=4, 23) hybrid liposomes on the basis of fluorescence polarization measurements. These results suggest that the inhibitory effects of the hybrid liposomes on the growth of HF cells should be related to the membrane fluidity. No toxicity to normal rats in vivo was observed in the experiment using 90mol% DMPC/10mol% C14 (EO)7 or 90mol% DMPC/10mol% C12 (EO)12 hybrid liposomes.

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