YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
漢薬・地膚子の研究(第1報)地膚子の70%エタノール抽出エキスの抗掻痒作用と有効成分の探索
久保 道徳松田 秀秋戴 岳井戸 康子吉川 雅之
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ジャーナル フリー

1997 年 117 巻 4 号 p. 193-201

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The antipruritogenic effect of the 70% ethanol extract obtained from Kochiae Fructus (fruits of Kochia scoparia) and its active components were investigated on a compound 48/80-induced pruritogenic model in male ddY strain mice. The extract (200, 500 mg/kg, p.o.) inhibited the scratching behavior as a pruritogenic indicator. Oleanolic acid oligoglycoside, momordin Ic, isolated from the extract also exhibited the inhibition. These results suggest that Kochiae Fructus could be used as an antipruritogenic agent and its inhibitory effect may be partially attributed to momordin Ic.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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