キャピラリー電気泳動による医薬品迅速分析 : 塩酸ジルチアゼム及び塩酸トリメトキノール製剤の含量均一性試験並びに定量

抄録

We applied capillary electrophoresis (CE) to quantify and examine the content uniformity of ingredients of pharmaceutical formulations (diltiazem hydrochloride tablets and trimetoquinol hydrochloride tablets), and also studied separation of enantiomers through the addition of dextrin or cyclodextrin (CD) as a chiral selector. We evaluated these methods in the light of testing procedures and system suitability described in the USP forum. The fast assay and content uniformity of both tablets, including optical purity testing, were performed within 300s. From the results of the system suitability testing, content uniformity and assay, these CE methods were found to be useful as an alternative to the conventional HPLC method.