YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Pyridin-又はChinolin-N-oxydのγ-位Arylsulfid及びArylsulfon誘導体の合成
板井 孝信
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ジャーナル フリー

1949 年 69 巻 12 号 p. 545-550

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By the application of p-nitrothiophenol, 4-mercaptoquinoline-N-oxide, 2-mercapto-4, 6-dimethylpyrimidine, 2-mercapto-4-methyl-thiazole and 2-mercapto-4, 5-dimethylimidazole to 4-chloropyridine- or quinoline-N-oxide easily gave corresponding sulfides which were then oxidized to sulfones. (However, sulfone of 4, 6-dimethylpyrimidine were not obtained). p-Nitrophenyl derivative was reduced to p-aminophenyl-pyridyl- or -quinolyl-sulfone. Antibacterial action of these compounds are being tested. Decomposition of p-nitrophenyl-pyridyl-(4)-sulfide-N-oxide by Na-ethoxide is also described.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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