YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Vitamin B1の作用機構の研究 (第1報)
Vitamin B1の酸化について. その1
松川 泰三岩津 岳夫
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1949 年 69 巻 12 号 p. 550-554

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a) Iodine oxidation of Vitamin B1 hydrochloride with application of 3mol. NaOH gave “aneurin disulfide”, which containes 2mol. of crystal water and has no certain melting point. However, treatment absolute EtOH or drying for a long period of time, gives an anhydride of decompn. 179°. Acetylation with acetic anhydride gives diacetate, decompn. 155°. An attempt to synthesize this diacetate by other method to determine its structure was unsuccessful.
b) Air oxidation of Vitamin B1 with application of 3mol. NaOH gave, instead of “Aneurin disulfide”, Vitamin B1 half-chloride, m.p. 125-6°, 2-methyl-4-amino-5-aminomethyl-pyrimidine and crystals of unknown structure with m.p. 224°. The same process with the application of 2mol. NaOH on Vitamin B1 hydrochloride gave crystals of m.p. 239° instead of “Aneurin disulfide”. The former crystals give positive thiochrome reaction when cysteine is applied.

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