YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
p-Toluenesulfonic Acidのα-Diethylamino-δ-pentanolエステルに依るアニリン及6-Methoxy-8-aminoquinolineのα-Diethylamino-δ-pentyl化に就いて
谷 千秋
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ジャーナル フリー

1949 年 69 巻 12 号 p. 555-557

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Esters of p-toluenesulfonic acid of aminoalcohols such as α-diethylamino-δ-pentanol which has a tertiary nitrogen atom of strong basicity cannot be prepared by the ordinary method of esterification for p-toluenesulfonic acid. It is necessary, in these cases, to close the basicity of its tertiary nitrogen atom by salt formation and then reacting for a long period of time at a comparatively high temperature. The author has found that the α-diethylamino-δ-pentylation of the amino group of aniline or 6-methoxy-8-aminoquinoline by the use of this ester cannot be carried out by the method described in D.R.P. and that it is necessary to use a much higher temperature and a longer reacting time.

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