エチレンヂアミン型化合物の合成研究

抄録

Syntheses of following compounds are described. These compounds were tested for their antihistaminic activities and it was found that their activities were very weak compared to benadryl, especially in those compounds in which no aromatic substituents are present in N. Compounds obtained were: N-(β-diethylaminoethyl)-α-pyrrolidone; N-(β-dimethylaminoethyl)-α-pyrrolidone; N-(β-dimethylaminoethyl)-α-pyridone, -α-piperidone, -piperidine; N-(β-dimethylaminoethyl)-phthalimidine; N-(β-dimethylaminoethyl)-α-quinolone, -3, 4-dihydroquinolone-(2), -tetrahydroquinoline; 6, 7-methylenedioxy-3-methyl-2-(β-dimethylaminoethyl)-3, 4-dihydroisoquinolone-(1); 6, 7-methylenedioxy-3-methyl-2-(β-dimethylaminoethyl)-1, 2, 3, 4-tetrahydroisoquinoline.