YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
イソヒノリン類の合成研究 (第2報)
7-Methoxy-8-isopropyl-1, 5-dimethyl-3, 4-dihydroisoquinolineの合成
石渡 三郎鈴木 輝一
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1950 年 70 巻 4 号 p. 197-199

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There has been no evidence of a hydroisoquinoline compound having iso-propyl radical in its 8-position having been synthesized and this was accomplished by the authors by taking thymol as the starting material. This was led to thymotinaldehyde by the Gattermann's method, methylated with (CH3)2SO4, condensed with acetone and reduced by electrolytic hydrogenation. The oxime of this reduced product was treated with P2O5 or POCl3 in toluene solution to obtain 8-isopropyl-7-methoxy-1, 5-dimethyl-3, 4-dihydroisoquinoline.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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