YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Synthetic Studies on the Sulfanilamide Group. VII
Reactions of bis-[Arylsulfonyl]-thiazolone-imide (2) with Alcohols in the Presence of Guanidine Carbonate
Kyosuke TsudaSusumu SatoHideo OkedaSaburo Motoyoshi
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1950 年 70 巻 7-8 号 p. 425-432

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1) Bis-[aryl-sulfonyl]-thiazolone-imide (2) reacts with methanol in the presence of guanidine carbonate to yield 3-methyl-thiazolone-aryl-sulfonylimide (2) as a chief product of the reaction.
2) Ethyl, allyl, n-butyl, isoamyl and benzyl alcohols, and ethylene glycol, have been found to react in a similar manner to give 3-alkylated 2-arylsulfonylaminothiazole.
3) It has been shown that guanidine carbonate catalyzes alkylation of acetosulfathiazole with arylsulfonyl ester to yield 3-alkylated derivatives.
4) A possible mechanism is suggested to account for these reactions.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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