クロルアンフェニコール合成研究 (第10報)

Transacylationによる1-p-Nitrophenyl-2-amino-1, 3-propanediolのN-アシル化

抄録

By heating dl-, d- and l-1-p-nitrophenyl-2-acetylamino-1, 3-propanediol (II) and excess of dichloroacetic acid in butanol, dl-, d- and l-1-p-nitrophenyl-2-dichloroacetylamino-1, 3-propanediol (chloramphenicol) (I) was obtained in 31% yield. In the same manner (I) was obtained in 37% yield from dl-1-p-nitrophenyl-2-formylamino-1, 3-propanediol (III). The same reaction on dl-1-p-nitrophenyl-2-benzoylamino-1, 3-propanediol (IV) ended in the recovery of the unreacted material.