1951 年 71 巻 2 号 p. 113-115
The influences of some drugs upon M. tuberculosis and the measurement of the amount of oxygen consumption, measured by the Warburg's manometer, and at the same time, the growth inhibiting activities using Kirchner's culture medium, in which 10% of serum was added, were compared. 31 compounds were tested; i.e. 10 of resorcinol compounds; 7 of lichen, substances 6 of coumarin compounds, 8 of plant components and synthesized products. There are many types in consuming oxygen, and among them usnic acid, monochlorocyclohexylresorcinol, showed the strongest inhibiting action to oxygen consumption. Usnic acid and p-aminosalicylic acid were the strongest in inhibiting growth, 2, 4-dihydroxy-3-chloro-5-n-amylbenzaldehyde, 2, 4-dihydroxy-3-chloro-5-n-hexylbenzaldehyde followed these products. It was shown that the inhibiting action to oxygen consumption and the growth inhibiting activities were not always parallel.