YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
7-Oxy-6-alkyl-cumarin類の合成について
藤川 福二郎中島 邦夫
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1951 年 71 巻 2 号 p. 67-69

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Starting with 2, 4-dihydroxy-5-alkyl-benzaldehydes, following were prepared by the Perkin's reaction: 7-Acetoxy-6-methyl-coumarin, 7-acetoxy-6-ethylcoumarin, 7-acetoxy-6-n-butyl-coumarin, 7-acetoxy-6-isoamylcoumarin, 7-acetoxy-6-n-amylcoumarin, and 7-acetoxy-6-n-hexylcoumarin. Deacetylation gave the respective 7-hydroxy compounds: -6-methyl-, m.p. 246°; -6-ethyl-, m.p. 156°; -6-n-butyl-, m.p. 140°; -6-isoamyl-, m.p. 118°; -6-n-amyl-, m.p. 96°; and 6-n-hexyl-m.p. 100°. 7-Hydroxy-6-n-heptylcoumarin, m.p. 103°, and the above described hydroxycoumarins except 6-methyl derivative were also synthesized by Pechmann reaction from 4-alkylresorcinols, malic acid and H2SO4.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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