異環アミノ化合物のヴアンスライク法による定量
1951 年 71 巻 2 号 p. 82-84
詳細
1951 年 71 巻 2 号 p. 82-84
An attempt was made to apply the van Slyke's method used in the quantitative determination of amino acids for heterocyclic amino compounds. 2-Aminopyridine derivatives were able to be determined and were not affected by the presence of other substituents. Diazonium compound of 3-aminopyridine was stable but its stability was influenced by both temperature and other substituents. 2-Aminothiazole derivatives can also be determined, but about twice the theoretical amount of gas is produced from 2-amino-4-methylthiazole. Hydrogen in 5-position was assumed to take part in this reaction, since 2-amino-4-methyl-5-ethanol-thiazole gave the same result as for 2-aminothiazole. It was found difficult to liberate nitrogen gas from guanidine by van Slyke's method, but when 2-aminopyrimidine derivatives were produced by pyrimidine nucleus formation, nitrogen gas was liberated quantitatively. Diazonium compound of 4-aminopyrimidine derivatives was stable.
