アミノイソヒノリン誘導体の合成研究 (第1報)
1-Phenyl-6, 7-dimethoxy-isoquinolyl-3-carbamic Acid Benzyl Esterの鹸化
1951 年 71 巻 5 号 p. 329-331
詳細
1951 年 71 巻 5 号 p. 329-331
Three kinds of aminoisoquinoline derivatives having amino radical in 1-, 3- or 4-position of N-containing ring were synthesized in order to examine their chemical properties and physiological activities. Ethyl 1-phenyl-6, 7-dimethoxyisoquinoline-3-carboxylate was prepared and led to benzyl 1-phenyl-6, 7-dimethoxyisoquinolyl-3-carbamate by the usual method through its hydrazide and azide. Finally, 1-phenyl-3-amino-6, 7-dimeth-oxyisoquinoline was obtained by the Sugasawa's improved method of the Curtius degradat on. The saponification of benzylurethane was made by treatment with a mixture of 20% HCl and glacial AcOH (1:1) or by a catalytic reduction with Pd in a good yield.
