クマリン誘導体の薬品的研究 (第2報)
Coumarin, 2-Thiocoumarin, 4-Methylcoumarinの毒性について
1951 年 71 巻 6 号 p. 596-601
詳細
1951 年 71 巻 6 号 p. 596-601
The toxicities of coumarin, 2-thiocoumarin and 4-methylcoumarin were determined with mice by the method of calculations postulated by Behrens-Kärber and Van der Waerden. It was found that coumarin was the most toxic, followed by 2-thio- and 4-methyl-coumarin. Various methods of calculating LD50, viz. Behrens-Kärber's, Van der Waerden's and Bliss', were compared for their precision and practicability and found that Van der Waerden's method was the most suitable for a routine assay.
