抗ヒスタミン剤の研究 (第3報)
N,N-Dimethyl-N´-benzyl-N´-(2-pyrimidyl)-ethylenediamine類の合成
1952 年 72 巻 11 号 p. 1444-1447
詳細
1952 年 72 巻 11 号 p. 1444-1447
2-Benzylaminopyrimidine was prepared by the application of propargyl aldehyde to benzylguanidine, and condensation with dimethylaminoethyl chloride gave N, N-dimethyl-N′-benzyl-N′-(2-pyrimidyl)-ethylenediamine. By a similar method, compounds containing methoxyl, bromine, chlorine, and fluorine in the para-position of the benzyl group were prepared. Application of cyanamide to N, N-dimethyl-N′-benzylethylenediamine gave 1-dimethylaminoethyl-1-benzylguanidine, reaction of propargyl aldehyde to which yielded N, N-dimethyl-N′-benzyl-N′-(2-pyrimidyl)-ethylenediamine. Pharmacological tests revealed that the compound possessing fluorine in the para-position of the benzyl group had the most strongest antihistamine acitivity.
