結核化学療法剤の研究 (第1報)
ジオキシ及びトリオキシ安息香酸類の合成
1952 年 72 巻 11 号 p. 1520-1522
詳細
1952 年 72 巻 11 号 p. 1520-1522
Some isomers of di- and tri-hydroxybenzoic acids were prepared to test their activities on tubercle bacilli. Of the compounds prepared, 2, 3, 6-trihydroxybenzoic acid is unknown in literature, whose preparation from 2, 6-dihydroxybenzoic acid by means of alkaline persulfate oxidation was found to yield no crystalline product. The methylation of the crude product with dimethyl sulfate finally yielded 2, 3, 6-trimethoxybenzoic acid.
