Abstract
For the purpose of preparing antispasmodics with strong effect and small toxicity, glycerol ethers of nitrogen-free bicyclic compounds were prepared and pharmacological tests were carried out. Of the new compounds prepared, 3-(1, 2, 3, 4-tetrahydro-7-naphthyloxy)-1, 2-propanediol was found to be better than Myanesin in slackening and paralysing the muscles, toxicity, action time, safety rate, and inhibition of convulsions induced by spasmodic poisons. 3-(1, 2, 3, 4-Tetrahydro-8-naphthyloxy)-1, 2-propanediol was found to be the next, with properties slightly lower than those of Myanesin. Such actions were found to be weak in compounds of this series such as 3-methylphenoxy-, 3-m-propylphenoxy-, and 3-m-butylphenoxy-1, 2-propanediols.
