含窒素環化合物の合成 (第66報)

フェニルピリヂルエーテル類について その2

抄録

By the respective condensation of the potassium salts of phenol, nitrophenols and chlorophenols to 2, 3-dichloro-5-nitropyridine in alcohol, eight kinds of phenyl (nitrophenyl or chlorophenyl)-3′-chloro-5′-nitropyridyl-(2′) ethers were obtained, the reduction of which yielded the corresponding phenyl (aminophenyl or chlorophenyl)-3′-chloro-5′-aminopyridyl-(2′) ethers. 2-Hydroxy-3-chloro-5-nitropyridine was obtained by the chlorination of 2-hydroxy-5-nitropyridine, treatment of which with a mixture of phosphorus pentachloride and phosphoryl chloride yielded 2, 3-dichloro-5-nitropyridine. The latter yielded 2-methoxy-3-chloro-and 2-ethoxy-3-chloro-5-nitropyridines. Deëthylation. of the latter yields 2-hydroxy-3-chloro-5-nitropyridine.