駆虫薬の合成研究 (第12報)
6-クロル-4-シクロヘキシルレゾルシンのクロル誘導体に就いて その3
1952 年 72 巻 7 号 p. 858-861
詳細
1952 年 72 巻 7 号 p. 858-861
Chlorination of 6-chloro-4-cyclohexylresorcinol with sulfuryl chloride gives an unstable intermediate (I), possessing one phenolic hydroxyl radical. Its methylation with diazomethane, followed by catalytic reduction results in the formation of a mono-methyl ether (V) of 6-chloro-4-cyclohexylresorcinol. In order to determine the relative positions of the phenolic hydroxyl and the methoxyl group in (V), various reactions were carried out from which (V) was assumed to be 6-chloro-4-cyclohexylresorcinol-3-methyl ether, showing the phenolic hydroxyl to be present in the 1-position and the methoxyl at 3-position.
