医薬品原料としてサフロールの利用研究
(第6報) ヂアルキルアミノエチル基を有するイソキノリン類の合成
1952 年 72 巻 7 号 p. 939-941
詳細
1952 年 72 巻 7 号 p. 939-941
Ortho, meta and para derivatives of 1-diethylaminoethoxyphenyl-3-methyl-6, 7-meth-ylenedioxyisoquinoline (V) and the dimethylamino compounds (VI) were prepared by reacting dimethyl- and diethyl-aminoethyl chlorides with 1-hydroxyphenyl-3-methyl-6, 7-methylenedioxyisoquinolines (IV), respectively, using sodium ethoxide as a condensing agent. Diethylaminoethyl 1-methyl-6, 7-methylenedioxyisoquinoline-3-carboxylate (VIII) was obtained by the trans-esterification between methyl 1-methyl-6, 7-methylenedioxy-isoquinoline-3-carboxylate (VII) and diethylaminoethanol. Biological tests of (V), (VI), (VIII) and methobromides of (V) and (VI) are now in progress.
