Vitamin B1関係化合物の研究 (第4報)
3-〔2´-Methyl-4´-aminopyrimidyl-(5´)〕-methyl-4-methyl-5-β-hydroxyethyl-thiothiazolone-(2)の過酸化水素酸化によるVitamin B1の合成
1952 年 72 巻 7 号 p. 966-968
詳細
1952 年 72 巻 7 号 p. 966-968
An addition of 3 moles of hydrogen peroxide to the suspension of 1 mole of 3-[2′-methyl-4′-aminopyrimidyl-(5′)]-methyl-4-methyl-5-β-hydroxyethyl-thiothiazolone-(2) (I) in water, at 25-35°, results in generation of heat and hydration of the crystals. Evaporation of the reaction solution under a reduced pressure and addition of absolute alcohol to the residue result in the precipitation of thiamine sulfate (II). Treatment of the above reaction product with BaCl2 or Ba(NO3)2 yields thiamine hydrochloride (III) or thiamine nitrate (IV).
