YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
数種の3-Carbamylpyridinium Halideのビタミン作用について
浮田 忠之進水野 伝一小坂 璋吾
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1953 年 73 巻 2 号 p. 111-115

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1) Pyridinium halides possessing a carbamyl group in the 3-position and methyl, isopropyl, benzyl, phenacyl, or p-bromophenacyl group in the 1-position were prepared, and their absorption spectra of the oxidation and reduction types were compared. The difference between the two types were not so large as at DPN.
2) Whether these synthetic compounds substituted with DPN in a few dehydrogenase system was examined but no such substitution was found to occur.
3) Cultural examinations were made with these compounds as to whether they possessed vitamin action towards Staphylococci and dysentery bacilli. It was found that phenacyl and p-bromophenacyl derivatives substituted with nicotinamide in 10-5-10-6 molar concentration to show a vitamin action.
4) Few considerations were offered as to the cause of the phenomenone as given in (3), in spite of experimental results obtained as iterated in (1) and (2).

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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