YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ズルフォンアミド剤合成の研究 (第5報)
N1-3,4-Dimethylbenzoylsulfanilamid (Irgafen) の合成に就いて
高取 吉太郎山田 保雄
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1953 年 73 巻 2 号 p. 115-118

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A new synthetic method for the preparation of N1-3, 4-dimethylbenzoylsulfanilamide (Irgafen) by the combination of the following processes: An oily substance, Camphren, is obtained by the steam distillation of 1 part of camphor with 4 parts of conc. sulfuric acid; oxidation of Camphren with sodium hypochlorite to 3, 4-dimethylbenzoic acid, which is derived to the phenyl ester; fusion of phenyl 3, 4-dimethylbenzoate, sulfanilamide, and alkali carbonate, or phenyl 3, 4-dimethylbenzoate and alkali salt of sulfanilamide, to obtain the objective Irgafen.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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