チアゾール誘導体の研究 (第2報)
2-Hydrazinothiazole誘導体の合成
1953 年 73 巻 2 号 p. 166-169
詳細
1953 年 73 巻 2 号 p. 166-169
A series of compounds in which the 2-position of the thiazole ring was bonded to sulfanilamide through hydrazino group were prepared in order to obtain effective antitubercular preparations. Deacetylation of thiazole compounds, obtained by the condensation of p-acetaminobenzenesulfonyl thiosemicarbazide with α, β-dichloroethyl ether, monochloroacetone, ω-bromoacetophenone, ethyl bromoacetoacetate, and ethyl chloroacetate, respectively yielded 2-(p-aminobenzenesulfonyl)-hydrazino-thiazole, -4-methylthiazole, -4-phenylthiazole, -4-methyl-5-carbethoxythiazole, and -4-thiazolidone. Of these compound, the 4-thiazolidone derivative showed a remarkable action in inhibiting the growth of tubercle bacilli in vitro.
