YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
p-アミノメチルフェニルメチルスルホンとサルファ剤の塩に就いて
石館 守三百瀬 勉井上 義一
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1953 年 73 巻 2 号 p. 202-204

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Based on the theory of synergic effect of sulfa drugs, three new salts of p-aminomethylphenyl methyl sulfone with sulfanylthiourea, sulfacetamide, and sulfathiazole were prepared, and their X-ray diffraction data and physical constants were determined. The antibacterial effects in vitro of these compounds were compared with those of basic components in artificial medium. No significant synergism was found in in vitro experiment, as compared to each component, but it was expected that the remarkably increased solubility of these salts might produce some effect on the mode of action in vivo.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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