Vitamin B₁及び諸関係化合物の研究 (第42報)

3-(2´-Methyl-4´-amino-pyrimidyl-5´)-methyl-4-methyl-5-β-hydroxyethylthiazol-2-thionに対する過酸化水素の作用

抄録

3-(2′-Methyl-4′-aminopyrimidyl-5′)-methyl-4-methyl-5-β-hydroxyethylthiazol-2-thion was treated with hydrogen peroxide at pH 7.0, 8.0 and in a strongly alkaline range to examine the difference in the products obtained at different pH ranges. At the same time, the formation mechanism was also assumed. Confirmation of the products was made chiefly by the paper partition chromatography, with isolation of some of the products. The products formed were as follows:
At pH 7.0-Vitamin B₁ disulfide (VI), vitamin B₁ (II) (in minute amount), thiochrome (IV) (in minute amount).
At pH 8.0-Thiamine-thiazolone (III) (in large amount), vitamin B₁ disulfide (VI), thiochrome (IV), vitamin B₁ (II) (in minute amount).
In strongly alkaline range-Thiamine-thiazolone (III) (in extremely large amount), thiochrome (IV), 2-methyl-4-amino-5-aminomethylpyrimidine (VII) (in minute amount).