Choline誘導体の研究 (第1報)
Glutamylcholineその1
1953 年 73 巻 4 号 p. 397-400
詳細
1953 年 73 巻 4 号 p. 397-400
Glutamylcholine was prepared from N-carbobenzoxyglutamic anhydride and choline chloride. Examination of the product by the paper partition chromatography showed the formation of two kinds of esters. Considering this reaction formulae, they were assumed to be the esters of α-and γ-choline. In order to examine the general properties of α-and γ-derivatives of glutamic acid, their methyl, ethyl, and propyl esters, amides, and hydrazides were prepared. The paper partition chromatogram always gave smaller Rf values for γ-derivatives than those of α-derivatives. Coloration with ninhydrin were reddish purple for γ-, and yellowish violet to violet for α-derivatives. From these results, it was assumed that the two esters mentioned above were glutamyl-(γ)-choline with spot at Rf 0.07-0.09, and glutamyl-(α)-choline with a spot at Rf 0.11-0.12.
