含硫黄ピリジン誘導体について (第38報)

ピリド-2,3:4´,5´-チアゾール類及びピリジルスルホン類の合成

抄録

1) Boiling of 2′, 6-diaminopyrido-2, 3:4′, 5′-thiazole in diluted sodium hydroxide solution resulted in the formation of 2, 6-diamino-3-mercaptopyridine which underwent autoxidation and changed to 2, 2′, 6, 6′-tetramino-3, 3′-dipyridyl disulfide. With the intermediate 3-mercapto derivative as the material, 2′-methyl-6-aminopyrido-2, 3:4′, 5′-thiazole and methyl 2, 6-diaminopyridyl-(3) sulfone were prepared.
2) Application of dimethyl sulfate or methyl iodide to the sodium mercaptide of 2-mercapto-3-amino-6-chloropyridine resulted in the formation of structurally unknown crystals, m.p. 286°(decomp.). The 3-acetamino derivative yielded methyl 3-amino-6-chloropyridyl-(2) sulfone.
3) Application of dimethyl sulfate or methyl iodide to the sodium salt of 2-mercapto-3-amino-6-ethoxypyridine resulted in the formation of structurally unknown crystals, m.p. 203-204°, and 2-methylmercapto-3-amino-6-ethoxypyridine. Application of ethyl iodide to the free base of the above 2-mercapto derivative also yielded structurally unknown crystals, m.p. 160-161°, and 2-ethylmercapto-3-amino-6-ethoxypyridine.
4) Methyl 3-amino-6-ethoxypyridyl-(2) sulfone was prepared.