クマリン誘導体の薬品的研究 (第7報)

蛔虫に対する作用機序に就いて その2

抄録

Action of 4-methylcoumarin, coumarin-3-carboxylic acid diethylamide, and sodium barbital against ascaris was observed with muscle nerve, muscle preparation, and the forward motion of ascaris in a glass tube, and following conclusions were drawn:
1) 4-Methylcoumarin gave a transitory stimulation, and then strong papalysis in samples. The stimulation is assumed to chiefly affect the nerve system, and the paralytic action chiefly the muscles. In higher concentration, striking paralytic action was seen to effect the forward motion of ascaris.
2) Coumarin-3-carboxylic acid diethylamide showed only a very weak paralytic action in samples and the locus of action seems to be chiefly in muscles. Practically no effect was seen in the forward motion of ascaris.
3) Sodium barbital showed a medium paralytic action in samples, which seems to be chiefly musculotropic.